The doctor-patient relationship constitute one of the foundations of contemporary medical ethics. It is the cornerstone of the practice of medicine and essential for delivering high-quality health care. In the current era, the financial targets, sophisticated investigations, media, and internet, all distract from the central, human interaction between physician and patient. Good doctor–patient communication is mandatory in all branches of medicine. Obtaining informed consent must be culturally sensitive, and is the first step to an appropriate communication respecting the patient’s values. Protecting confidentiality has a vital importance in Islam. In specific circumstances, an individual can be lawfully authorized to release negative information about specific individuals. When treating a Muslim female patient, recognizing and understanding her concerns about modesty is invaluable in developing an unruffled physician-patient relationship. Breaking bad news will always be one of the most intimidating tasks facing physicians and drastically affect patients and their loved ones. Formal training in breaking bad news is strongly encouraged.